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Listed below are the Major League Baseball players who have hit 2 Grand slams in the same game.
Notes
| Date | Player | Team |
| May 24, 1936 | Tony Lazzeri | New York Yankees, AL |
| July 4, 1939 | Jim Tabor | Boston Red Sox, AL |
| July 27, 1946 | Jim Gentile | Baltimore Orioles, AL |
| July 3, 1966 | Jim Northrup | Detroit Tigers, AL |
| June 26, 1970 | Frank Robinson | Baltimore Orioles, AL |
| September 4, 1995 | Robin Ventura | Chicago White Sox, AL |
| August 14, 1998 | Fernando Tatis | St. Louis Cardinals, NL |
| May 10, 1999 | Nomar Garciaparra | Boston Red Sox, AL |
| July 29, 2003 | Bill Mueller | Boston Red Sox, AL |